Laser hair removal focuses on the endogenous chromophore melanin, which is mainly found in
the hair shaft, with a small amount present in the upper third of the follicular epithelium (Figure
When an appropriate energy source (such as a laser) is directed at the skin, light is
primarily absorbed in the hair shaft melanin. Heat is generated and diffuses to the surrounding
follicular epithelium. A similar principle applies to laser treatment of vascular lesions, where
the heat generated after absorption by hemoglobin is transferred from the blood to the vascular
endothelial cells.
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